A breakthrough in safely delivering therapeutic DNA to cells could transform treatment for millions suffering from common chronic diseases like heart disease, diabetes, and cancer. A new process that ...

Researchers have developed a new lipid nanoparticle design that directs mRNA to the pancreas by exploiting the organ’s own filtration barrier, a strategy that sidesteps the liver-trapping problem that ...

Nucleic acids such as DNA and RNA play a central role in gene therapies and vaccines. They store and transmit biological information. In order for them to work in the body, they must enter the cells ...

Researchers are redesigning lipid nanoparticles to do more than shuttle mRNA into cells, with preclinical studies suggesting engineered particles can influence immune metabolism in ways that may ...

Better mRNA release inside cells boosts vaccine and gene editing performance, enabled by redesigned lipid molecules that grip cargo tightly but let go quickly once inside cells. For vaccines, this was ...

Dendritic cells (DCs) are among the first immune sentinels to detect viruses, bacteria, or other challenges. These specialized messengers alert T cells while orchestrating either a measured calm or a ...

A trio of common amino acids may hold the key to unlocking far more powerful gene therapies. Researchers found that adding them to lipid nanoparticles can boost mRNA delivery up to 20-fold and push ...

Interest in lipid nanoparticles (LNPs) as delivery vehicles for precision therapies in genetic diseases and cancers remains at an all-time high. Now, scientists from the University of Pennsylvania, ...

Researchers hold models of the aromatic rings they added to lipid nanoparticles, which could reduce the dosage mRNA vaccines need to achieve immunity. Penn Engineers have redesigned a key component of ...

A stabilized mRNA carrier turns tumor injection into broader immune activation by extending vaccine delivery to lymph nodes ...