Saddest movie ever 💔 🎥: My Sister’s Keeper, released in 2009 and directed by Nick Cassavetes, is a poignant family drama adapted from Jodi Picoult’s bestselling 2004 novel. The story follows Anna Fitzgerald (Abigail Breslin), a young girl who was conceived through in vitro fertilization to be a perfect genetic match for her older sister, Kate (Sofia Vassilieva), who has been battling leukemia since childhood. From birth, Anna undergoes countless medical procedures—blood, bone marrow, and more—